Congress organising committee
ANDRÉ
COHEN
DUVAL
RENAUD
How to enjoy our congress?
Attend the congressOn site
Please register via the form before November 20, 2023.
Free registration, number of places limited.
Amphithéâtre ADICARE
Institut de Cardiologie - Groupe Pitié-Salpêtrière
56, boulevard Vincent Auriol
75013 PARIS
Watch the live broadcastOn the website
The congress will be broadcast live on this website. To watch the event, all you need to do is create a free account.
Connect on D-Day and ask your questions to the speakers via the Live Chat!
Scientific program
THURSDAY NOVEMBER 30 01:30 to 06:15 PM (UTC +2)
Introduction
Main goals of this First interSIRIC meeting dedicated to MSI Cancers
Thierry ANDRÉ Hôpital Universitaire Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France, Romain COHEN Hôpital Universitaire Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France, Alex DUVAL Centre de Recherche Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France, Florence RENAUD Hôpital Universitaire Pitié-Salpêtrière, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France
Session 1: MSI and CANCER - ADVANCES IN THE PRECISION DIAGNOSIS
Chairs: Pierre LAURENT-PUIG Hôpital Européen Georges-Pompidou, SiRIC CARPEM, Paris, France, David TOUGERON Hôpital Universitaire de Poitiers, Poitiers, France
Improving the detection of MSI in panCancer
Performance and limitations of conventional tools (Immunohistochemistry and PCR) for detecting MSI in pan-cancer: the need to develop new methods
Janick SELVES Oncopole CHU Institut Universitaire du Cancer, CRCT, Toulouse, France
Deep Learning-based biomarkers for MSI
Jakob Nikolas KATHER Technical University Dresden, Dresden, Germany
Microsatellite instability and Cancer: Use of Next Generation Sequencing for the diagnosis of this tumor phenotype and the identification of mechanisms underlying resistance to immune checkpoint inhibitors
Toky RATOVOMANANA Centre de Recherche Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France
Q&A
Session 1 : MSI and CANCER - ADVANCES IN THE PRECISION DIAGNOSIS
Chairs: Chrystelle COLAS Institut Curie, SiRIC CURIE, Paris, France, Florence COULET Hôpital Pitié-Salpêtrière, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France
Advances in the detection and prevention of Lynch and CMMRD syndrome (Hereditary Predisposition to MSI tumors)
Recognizing Lynch Syndrome by the immune profile of patients
Matthias KLOOR University Hospital Heidelberg, Heidelberg, Germany
Diagnosis of CMMRD by NGS Profiling of Mononucleotidic Microsatellites in Germline DNA
Olivier BUHARD Centre de Recherche Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France
Influence of additional susceptibility variants on cancer risk in Lynch syndrome
Patrick BENUSIGLIO Hôpital Universitaire Pitié-Salpêtrière, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France
MSH3: a confirmed predisposing gene for adenomatous polyposis
Marie-Charlotte VILLY Institut Curie, SiRIC CURIE, Paris, France
Q&A
Coffee break
Session 2: MSI and CANCER - UNDERSTANDING GENOMICS
Chairs: Ada COLLURA Centre de Recherche Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France, Laurent LE CAM Institut de Recherche en Cancérologie de Montpellier, SiRIC Montpellier Cancer, Montpellier, France
MMRd in Gliomas: From Genomics to Clinics
Mehdi TOUAT Hôpital Universitaire Pitié-Salpêtrière, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France
Inducing MMR deficiency in MSS colorectal cancer
Filippo PIETRANTONIO Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Beyond genetic instability, towards the definition of the phenotypic heterogeneity of colorectal MSI tumors
Rémy NICOLLE Centre de Recherche sur l’Inflammation, SiRIC InsiTu, Paris, France
Q&A
Cis-Perturbation of Splicing Due To Microsatellite Instability In Colorectal Cancer
Hugo MONTEMONT Centre de Recherche Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France
Transcriptomic Signatures of MSI mCRC Predict Efficacy of ICI
Claire GALLOIS Hôpital Européen Georges-Pompidou, SiRIC CARPEM, Paris, France
Moving WRN inhibition towards precision medicine in microsatellite unstable cancers
Gabriel MATOS-RODRIGUES Institut Gustave Roussy, SiRIC EpiCure, Villejuif, France
Q&A
FRIDAY DECEMBER 1 09:00 to 12:15 PM (UTC +2)
Welcome coffee
Session 3: MSI and CANCER - ADVANCES IN THE PRECISION MEDICINE
Chairs: Jérémie LEFEVRE Hôpital Universitaire Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France, Florence RENAUD Hôpital Universitaire Pitié-Salpêtrière, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France
Tumor regression grading: classifications, practical issues and potential clinical impact in the context of MSI
Rupert LANGER Johannes Kepler Universität, Linz, Austria
Heterogeneity of tumor response with immune checkpoint inhibitors in MSI-H/dMMR tumors
Christelle DE LA FOUCHARDIÈRE Institut Paoli Calmettes, Marseille, France
Non-surgical strategies for patients with localized MSI cancers, methodological pitfalls
Romain COHEN Hôpital Universitaire Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France
Immune and molecular data in patients with localised MSI cancers treated with neoadjuvant immunotherapy: TRANS-IMHOTEP study
Clélia COUTZAC Centre Léon Bérard, SiRIC LyriCAN+, Lyon, France
Q&A
Synthesis
Using genomics for diagnosing and prognosing MSI cancers
Alex DUVAL Centre de Recherche Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France
Immune checkpoint inhibitors for treatment of patients with MSI cancers: a paradigm shift and a lot of questions for clinical practice
Thierry ANDRÉ Hôpital Universitaire Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France
Coffee Break
Roundtable discussion
This session will not be available online
