National Congress on Tumors with Microsatellite Instability

Replay

Congress organising committee

Thierry
ANDRÉ
Romain
COHEN
Alex
DUVAL
Florence
RENAUD

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Attend the congressOn site

Please register via the form before November 20, 2023.

Free registration, number of places limited.

Amphithéâtre ADICARE
Institut de Cardiologie - Groupe Pitié-Salpêtrière
56, boulevard Vincent Auriol
75013 PARIS

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Scientific program

THURSDAY NOVEMBER 30 01:30 to 06:15 PM (UTC +2)

Introduction

Main goals of this First interSIRIC meeting dedicated to MSI Cancers

Thierry ANDRÉ  Hôpital Universitaire Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France, Romain COHEN  Hôpital Universitaire Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France, Alex DUVAL  Centre de Recherche Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France, Florence RENAUD  Hôpital Universitaire Pitié-Salpêtrière, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France

Session 1: MSI and CANCER - ADVANCES IN THE PRECISION DIAGNOSIS

Chairs: Pierre LAURENT-PUIG  Hôpital Européen Georges-Pompidou, SiRIC CARPEM, Paris, France, David TOUGERON  Hôpital Universitaire de Poitiers, Poitiers, France

Improving the detection of MSI in panCancer

Performance and limitations of conventional tools (Immunohistochemistry and PCR) for detecting MSI in pan-cancer: the need to develop new methods

Janick SELVES  Oncopole CHU Institut Universitaire du Cancer, CRCT, Toulouse, France

Deep Learning-based biomarkers for MSI

Jakob Nikolas KATHER  Technical University Dresden, Dresden, Germany

Microsatellite instability and Cancer: Use of Next Generation Sequencing for the diagnosis of this tumor phenotype and the identification of mechanisms underlying resistance to immune checkpoint inhibitors

Toky RATOVOMANANA  Centre de Recherche Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France

Q&A

Session 1 : MSI and CANCER - ADVANCES IN THE PRECISION DIAGNOSIS

Chairs: Chrystelle COLAS  Institut Curie, SiRIC CURIE, Paris, France, Florence COULET  Hôpital Pitié-Salpêtrière, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France

Advances in the detection and prevention of Lynch and CMMRD syndrome (Hereditary Predisposition to MSI tumors)

Recognizing Lynch Syndrome by the immune profile of patients

Matthias KLOOR  University Hospital Heidelberg, Heidelberg, Germany

Diagnosis of CMMRD by NGS Profiling of Mononucleotidic Microsatellites in Germline DNA

Olivier BUHARD  Centre de Recherche Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France

Influence of additional susceptibility variants on cancer risk in Lynch syndrome

Patrick BENUSIGLIO  Hôpital Universitaire Pitié-Salpêtrière, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France

MSH3: a confirmed predisposing gene for adenomatous polyposis

Marie-Charlotte VILLY  Institut Curie, SiRIC CURIE, Paris, France

Q&A

Coffee break

Session 2: MSI and CANCER - UNDERSTANDING GENOMICS

Chairs: Ada COLLURA  Centre de Recherche Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France, Laurent LE CAM  Institut de Recherche en Cancérologie de Montpellier, SiRIC Montpellier Cancer, Montpellier, France

MMRd in Gliomas: From Genomics to Clinics

Mehdi TOUAT  Hôpital Universitaire Pitié-Salpêtrière, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France

Inducing MMR deficiency in MSS colorectal cancer

Filippo PIETRANTONIO  Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Beyond genetic instability, towards the definition of the phenotypic heterogeneity of colorectal MSI tumors

Rémy NICOLLE  Centre de Recherche sur l’Inflammation, SiRIC InsiTu, Paris, France

Q&A

Cis-Perturbation of Splicing Due To Microsatellite Instability In Colorectal Cancer

Hugo MONTEMONT  Centre de Recherche Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France

Transcriptomic Signatures of MSI mCRC Predict Efficacy of ICI

Claire GALLOIS  Hôpital Européen Georges-Pompidou, SiRIC CARPEM, Paris, France

Moving WRN inhibition towards precision medicine in microsatellite unstable cancers

Gabriel MATOS-RODRIGUES  Institut Gustave Roussy, SiRIC EpiCure, Villejuif, France

Q&A

FRIDAY DECEMBER 1 09:00 to 12:15 PM (UTC +2)

Welcome coffee

Session 3: MSI and CANCER - ADVANCES IN THE PRECISION MEDICINE

Chairs: Jérémie LEFEVRE  Hôpital Universitaire Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France, Florence RENAUD  Hôpital Universitaire Pitié-Salpêtrière, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France

Tumor regression grading: classifications, practical issues and potential clinical impact in the context of MSI

Rupert LANGER  Johannes Kepler Universität, Linz, Austria

Heterogeneity of tumor response with immune checkpoint inhibitors in MSI-H/dMMR tumors

Christelle DE LA FOUCHARDIÈRE  Institut Paoli Calmettes, Marseille, France

Non-surgical strategies for patients with localized MSI cancers, methodological pitfalls

Romain COHEN  Hôpital Universitaire Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France

Immune and molecular data in patients with localised MSI cancers treated with neoadjuvant immunotherapy: TRANS-IMHOTEP study

Clélia COUTZAC  Centre Léon Bérard, SiRIC LyriCAN+, Lyon, France

Q&A

Synthesis

Using genomics for diagnosing and prognosing MSI cancers

Alex DUVAL  Centre de Recherche Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France

Immune checkpoint inhibitors for treatment of patients with MSI cancers: a paradigm shift and a lot of questions for clinical practice

Thierry ANDRÉ  Hôpital Universitaire Saint-Antoine, IUC AP-HP.SU, SiRIC CURAMUS, Paris, France

Coffee Break

Roundtable discussion

This session will not be available online

How to improve research on MSI Cancers

With the support of

Logo Sorbonne Université
Logo APHP Sorbonne Université
Logo Bristol Myers Squibb
Logo Merck Group
Logo MSD
Logo MSInsight
Logo Owkin
Logo Promega
Logo Pierre Fabre
Logo Takeda
Logo Roche
Logo GSK

SiRICs partners

Logo SIRIC Curie Logo SIRIC LYriCAN Logo SIRIC Montpellier Cancer Logo SIRIC CARPEM
Logo SIRIC EpiCURE
Logo In Situ

Partners of SiRIC CURAMUS

Logo APHP
Logo Sorbonne Université
Logo Inserm
Logo CNRS
Logo APHP Sorbonne Université
Logo Institut Universitaire de Cancérologie
Logo Clip2 Galilée
Logo SU Médecine
Logo SU Sciences
Logo SU Lettres

SiRIC CURAMUS is financially supported by
(INCa-DGOS-INSERM-ITMO Cancer_18010)

Logo Institut National du Cancer
Logo Ministère Solidarités et Santé
Logo Inserm bis
Logo Aviesan